Scientist/Senior Scientist, Process Development and Manufacturing

Menlo Park, CA 94025

Posted: 10/14/2020 Employment Type: Contract-to-Hire Industry: Clinical & Scientific Job Number: 18040

Job Description


Scientist/Senior Scientist, Process Development and Manufacturing

 

Position Summary

The Scientist/Senior Scientist, Process Development and Manufacturing is responsible for driving results in a fast-paced environment by leading the scale-up activities and refining the process. 

Responsibilities
  • Responsible for process research and development of various mRNAs.
    • Evaluation of enzymes, plasmids and reagents to achieve required quality attributes of mRNA.
    • Evaluation of process steps and parameters in IVT, capping and purification of mRNA to achieve higher yield and purity.
    • Process research of novel approaches to produce mRNA
  • Scale up mRNA production process from milligrams scale to grams scale and eventually to 100+ g scale.
  • Set up GMP system for production of mRNA under development phase – appropriate cGMP.
  • Manufacture GMP batches for toxicology and clinical studies as necessary.
  • Perform mRNA testing as needed during process development and scale up.
  • Work closely with Formulation, LNPs process R&D, analytical R&D, quality and regulatory teams.


Qualifications
 
  • BS/MS with 6 to 8 years relevant experience (PhD with 2 to 5 years preferred) in making purifying and analyzing oligonucleotides, mRNAs at bench and larger scales.
  • Strong foundation in biochemistry, molecular biology, or related field.
  • Familiarity with cGMP requirement for early development is a plus.
  • Must be comfortable in a fast-paced small company environment with minimal direction.
  • Flexible, adapt to change, and work independently and as part of a multi-disciplinary team.
  • Self-starter with excellent interpersonal skills with demonstrated success in working collaboratively cross functionally in a matrix environment.
  • Multi-task, pay attention to details and produce high quality work under tight timelines.
  • Strong oral and written communication skills to support internal and external communications/presentations.
  • Prior experience leading teams preferred.

 

Meet Your Recruiter

Jesse Ashworth

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