Scientist/Senior Scientist, Gene Therapy

Menlo Park, CA 94025

Posted: 09/09/2019 Employment Type: Direct Hire Industry: Clinical & Scientific Job Number: 16390

Scientist/Senior Scientist, Gene Therapy

We are seeking a talented Scientist/Senior Scientist to join the Novel Vector Technologies team as we develop our technology towards a  variety of AAV gene therapy-based treatments. The ideal candidate should possess training and hands-on skills in molecular biology specifically in designing and optimizing viral capsids and/or gene expression cassettes including regulatable and tissue specific expression constructs. In addition, the candidate should have extensive experience in tissue culture (cell lines and primary cells) and analysis of in vivo expression of a transgene.

 

Essential duties and responsibilities include but are not limited to the following:
  • Develop AAV capsids and/or regulatory cassettes to improve and/or limit transgene expression to certain tissues
  • Independently design and execute experiments following appropriate laboratory procedures and produce competent and reproducible results to a high technical standard
  • Appropriately analyze and interpret results, and communicate scientific data
  • Maintain accurate records with minimum supervision
  • Participate in the development of assays for the characterization of AAV vector products, particularly in terms of expression upon gene transfer, in vitro (in vivo a plus)

Position Requirements and Experience:
  • Ph.D. in the Biomedical Sciences, biochemistry, virology or other relevant discipline and 5+ years of relevant academic or industry research experience after PhD degree.
  • Background in the area of gene therapy, in particular of AAV vectors
  • Strong knowledge base in molecular biology, biochemistry and immunology
  • Scientific competency as demonstrated by strong publication record in peer-reviewed journals
  • Expertise in a variety of laboratory techniques such as recombinant DNA technology, including qPCR, vectorology, DNA/RNA isolation and analysis; sterile tissue culture techniques; biochemical techniques including, Western Blot, flow cytometry, immunofluorescence, and ELISA
  • Experience with in vivo animal models is preferred and know-how with the baculovirus expression system is a plus
  • Detail oriented with excellent time management skills
  • Must be proactive, co-operative, and willing to work in a small team environment
  • Excellent verbal and written communication skills 

 

Jesse Ashworth

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