Research Associate/Sr. RA Gene Editing

Hayward, CA 94545

Posted: 11/07/2018 Employment Type: Contract-to-Hire Industry: Clinical & Scientific Job Number: 14146

Research Associate/Sr. RA Gene Editing

South San Francisco, CA (moving from Hayward in early 2019)

 

We are located in the San Francisco bay area, in the heart of the world’ s premier biotechnology research hub.  We offer a competitive compensation and benefits package, including aggressive participation in the growth of the company in the form of stock option grants.  This is an ambitious cutting-edge undertaking - we fully anticipate our company to become the world’ s leader in personalized adoptive T cell therapies for cancer and therefore key to the future of cancer treatment. These positions currently being recruited for our site in Hayward, CA, but we will be relocating to a new site by years ends.

 

Research Associate/Sr. RA – Gene Editing

The ideal candidate should be experienced the latest molecular cloning and sequencing techniques for the generation and analysis of transgenic T cells. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment and will communicate results to and coordinate efforts with a larger cross-disciplinary team of immunologists, biologists, engineers and bio-informaticians.

Responsibilities:
  • The candidate will be performing experiments to validate and improve the technology for gene editing (knock-in and knock-out) of endogenous and neoE TCRs, and analyzing the resulting data.
  • She/he must be able to communicate clearly and concisely, both verbally and in the form of written reports. The incumbent will aid in drafting protocols, and provide data for regulatory documentation to support clinical development.

Minimum Qualifications:
  • The ideal candidate will hold a Bachelor’ s degree with 4+ years’ experience, a Master’ s degree with 3+ years’ experience with career focus in cell or molecular biology, biochemistry, or molecular genetics.
  • Industry experience is preferred.
  • The candidate must have hands on experience with nucleic acid purification and use, including primer design, PCR and standard cloning.
  • The candidate should have experience in mammalian cell culture.
  • The candidate should be highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives.

Preferred Qualifications:

An incumbent with experience in the following areas is a plus:
  • High-throughput sequencing sample preparation and analysis
  • qPCR and/or ddPCR assay design, execution, for analysis of gene-edited cells
  • Large-scale plasmid DNA purification
  • Mammalian cell transfection
  • Primary T cell culture
  • Eukaryotic protein expression systems
  • Flow cytometry or FACS
  • Site-specific nucleases (e.g. CRISPR and TALENs) and resulting cellular and molecular analysis

Jesse Ashworth

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