Research Associate I/II - Bioengineering

South San Francisco, CA 94080

Posted: 05/13/2019 Employment Type: Contract-to-Hire Industry: Clinical & Scientific Job Number: 15677

Research Associate I/II - Bioengineering

 

We are currently recruiting for Research Associates and various levels to work in our impact groups. This position will report to the Principal Investigator of Impact Process and will be based in South San Francisco

Our team is developing cancer therapeutics consisting of tumor mutation-targeted T cells tailored to each patient. We isolate rare, tumor mutation (neoepitope) specific T cells generated by the patient’ s own immune system and discover the T cell receptors (TCRs) that confer this tumor specificity. We use non-viral, precision genome engineering methods that allow us to replace the endogenous TCRs of fresh T cells collected from the same patient, with neoepitope-targeted TCRs. When re-infused into the cancer patient, these cells can readily expand and differentiate into highly lethal anti-tumor effector T cells, enabling immediate tumor cell killing. They can also persist in the patient’ s immune system, enabling long-term immune surveillance to prevent future cancer recurrence.

 

The persons in this role will be responsible for the design and execution of critical path experiments for the discovery of neoEpitope and corresponding TCR, to be used for the manufacture adoptive cell therapeutics (ACT). These experiments will focus on flow cytometric analysis of patient samples and engineered T cells, and may also include operation of microfluidic devices, RT-PCR, and NGS analysis of single T cells. The ideal candidate should enjoy operating in an exceptionally dynamic and cooperative environment.

Minimum Qualifications:
  • The ideal candidate should hold a bachelor’ s degree with 4+ years’ experience, or hold a master’ s degree with 2+ year experience
  • Experience with at least two of: single cell technologies, FACS, RT-PCR, and fluid handling robots
  • Experience with microfluidics or immuno-oncology and T cell biology will be a plus
  • Highly goal-driven and the ability to handle delicate experiments
  • Able to do team work and communicate clearly and concisely, both verbally and in the form of written reports
  • Experience with at least one of: RT-PCR, microfluidics, and, fluid handling robots
  • The candidate should be highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives
  • Able to do team work and communicate clearly and concisely, both verbally and in the form of written reports
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