Associate Scientist, Assay Development Cell Biology

Menlo Park, CA 94025

Posted: 01/13/2020 Employment Type: Direct Hire Industry: Clinical & Scientific Job Number: 16964

Job Description


 

 

Job Description

Associate Scientist, Assay Development Cell Biology

Position Summary

We are looking for an Associate Scientist with knowledge of cell biology to join our team in our Redwood City office. This position reports to a Scientist/Team Leader.  This person will be working with Assay Development, QC, and Process Development.  This role is responsible for developing, qualifying, transferring, and troubleshooting cell-based assays in support of product characterization/release and bioanalysis.

What You’ ll Do
  • Work with senior scientific personnel to design, develop, qualify, troubleshoot, and transfer cell-based assays to internal and external scientists in some subset of the following categories (several positions are available): 
    • Drug potency assays
    • Virus-neutralizing antibody assays
    • Viral infection and transduction assays
    • Cell-based anti-drug antibody assays
    • Product characterization assays
    • Cell line development/subcloning
    • Infectivity/transduction assays
    • Immune cell activity assays
    • Cell banking
  • Participate in decisions on experimental approaches and interpretation of data.
  • Work collaboratively with different research and development departments to evaluate and implement new assay formats and/or technologies.
  • Perform internal sample analysis as needed in support of product characterization and preclinical studies.
  • Transfer assays and oversee work at Contract Research Organizations and the QC group.
  • Maintain current knowledge of regulatory requirements for bioanalytical and product characterization assays.
  • Write test procedures, documented standard test methods, SOPs, protocols, and technical reports.
  • Present project status updates in internal and external forums.
  • Maintain excellent documentation of laboratory activities.
  • Perform routine lab maintenance.
  • Other responsibilities may be assigned as needed.

About You
  • Minimum of a biological science or similar Bachelor’ s degree with 4-5 years’ experience in a biotech company, or a Master’ s degree with 2-3 years’ experience, or an equivalent combination of education and experience.
  • Experience in assay development is required.
  • Ability to read and extract information from published literature and internal reports is required.
  • Expertise is required in cell-based assays (sterile tissue culture techniques, transfection, transduction, maintaining, subcloning, and banking cells).
  • Knowledge of techniques such as flow cytometry and immunofluorescence are strongly desired.
  • Experience in the qualification/validation of quantitative assays and knowledge of FDA requirements is desired.
  • Broad knowledge of cell assay methods and biochemistry with application to gene therapy (for example, neutralizing antibody assays) is strongly desired.
  • Background in the area of retinal or genetic diseases is desired, with an understanding of AAV biology is a plus.
  • Must be a self-starter, proactive, co-operative, and proficient at working both independently and in a small team environment.
  • Proven initiative and demonstrated accountability in a fast-paced environment with high degree of flexibility.
  • Detail oriented with time management skills.
  • Excellent verbal and written communication skills.
  • Experience in presenting data through written reports and oral presentation.
  • Publication in a peer-reviewed journal or presentation at a conference is desired.
  • Proficiency with SoftMaxPro, GraphPad Prism, JMP, and other common analytical software desired.
  • Proficient with MS Office and other common office software.

 

 

 

Meet Your Recruiter

Felicia Id-Deen

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